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Friday, May 28, 2010
NIPER JEE SYLLABUS
NIPER EXAM PATTERN & SYLLABUS

Entrance pattern:
Well entrance consists of 200 questions in 2 hours. (Please check it in Brochure). Well questions will be very easy so no need to go in depth of the topic. Basic concepts based questions are asked. M. Pharma branches and M.B.A. has a common entrance paper. So read some general knowledge aspects also…………….
This syllabus is just like GATE entrance but more specific in Basic Chemistry instead of medicinal chemistry.
Specialization subjects: What to study…..

Medicinal chemistry and Bulk Drugs (Pharmaceutical Technology)
IUPAC nomenclature, R and S nomenclature, E and Z isomerism, atropiisomerism, Conformations
Hybridization, aromaticity, Huckel’s rule reaction mechanisms- Electrophilic, Nucleophilic, SN1, SN2, SNi, Elimination E1 E2 etc.
Ester hydrolysis, Aac1 Aac2……all eight mechanisms (Jerry march) Markovnikoves rule, Bredts rule, Stereoselectivity, stereospecificity, regioselectivity, chemoselectivity, chirality, stereochemistry, conformations, rearrangements, acids and bases.
Imine-enamine Tautomerism, keto-enol tautomerism, pericyclic reactions, racemic mixture, resolution methods.
Amino acids proteins, various methods for amino acid detection, Ninhydrin test, peptide sequencing, structures of amino acids, essential and nonessential amino acids,
Introduction to thermal methods of analysis like, TGA, DSC, DTA etc.
Carbohydrates classification, osazone test, mutarotation, etc,
Various Heterocycles, Heterocycle synthesis, reactions.
Introduction to Redox reactions.
Spectroscopy: (basics specially): Very very IMP topic. NMR, and C-NMR ranges from Morrison & Boyd or Pavia Mass -Basic concepts about various peaks M+1, molecular ion, base peak etc. (Silverstein) IR - Frequencies of various groups specially carbonyls. UV
Chromatography: Details of every chromatographic method.
Reaction kinetics, first second third and pseudo first order reactions, radio labeling for determination of mechanism.
Common condensation reactions like Aldol, Claisen Perkin, Dickmann, Darzen etc.
Other reactions like Cannizarro’s reaction, Prins reaction, especially reactions of carbonyl compounds.
References:
1. Jerry March
2. Morrison and Boyd (ESPECIALLY Peptide and Carbohydrate chemistry)
3. I. L. Finar Vol-I and Vol-II (Heterocyclic chemistry and organic synthesis)
4. Eliel

Natural Products:
In natural products more stress should be given on phytochemistry part rather than biological aspects.
Methods of extraction, isolation and characterization of natural products. Various separation techniques used for isolation of natural products.
Biosynthetic pathways.
Primary metabolites, their examples.
Secondary metabolites, various classes of secondary metabolites (e.g. Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins, anthocyanidines etc.). Here most imp. Part is chemistry of these classes.
Important therapeutic classes: antidiabetics, hepatoprotectives, immmunomodulators, neutraceuticals, natural products for gynecological disorders, anti-cancer, anti-viral (mainly anti-HIV), adaptogens etc.
Dietary antioxidants, Marine natural products, Plant growth regulators.
Spectroscopy: Basic concepts of UV, NMR, IR and Mass spectroscopy. Give more stress on IR and NMR.
Stereochemistry: Basic concepts.
Fischer, sawhorse and newmon projection formulaes.
Biological sources of important classes of natural products. (Selected ones only)
Standardization of natural products.
What is difference between natural products and pharmacognosy?
References:
1. For various therapeutic classes: Trease and Evans
2. For spectroscopy: Silverstein, Pavia, Kemp.
3. For stereochemistry: I.L. Finar vol-II

Pharmacology and toxicology:
Pharmacokinetics, pharmacodynamics, pharmacological effect, desired, undesired, toxic, adverse effects.
Bioavailability, bioequivalence, various factors of ADME. (From Bramhankar)
Drug metabolism: various pathways and other details.
Drug interactions, agonist, antagonist, partial agonist, protein binding, drug distribution, distribution volume, excretion pathways etc.
Pharmacological screening: general principles, various screening models, screening methodologies (in vitro and in vivo tests).
Mechanism of drug action, drug-receptor interaction.
Various adrenergic, cholinergic and other receptors
Detailed study of CNS pharmacology
Study of basis of threshold areas of work in NIPER in pharmacology dept. mentioned in brochure.
Diseases: study of the pharmacology of the diseases and drugs used with mode of action especially of diabetes, malaria, leishmaniasis, TB, hypertension, myocardial ischemia, inflammation, and immunomodualtion.
Chemotherapy and pathophysiology- knowledge of antibiotics, their mode of action and the microorganisms responsible for various common diseases.
Bioassay methods, various requirements. Brief knowledge of the statistical tests.
References:
1. Rang and Dale (ALL CHEMOTHERAPY CLASSES OF DRUGS. IF YOU READ THE WHOLE BOOK, then nothing else is needed)
2. F. S. K. Barar
3. Wilson and Griswold (for Mechanism)
4. Kasture (for Bioassay and Screening)

Pharmaceutics and formulation (Pharmaceuticl Technology)
Drug delivery systems (DDS): NDDS models, osmotic pumps, various release patterns eg. Controlled release, delayed release. Sustained release etc., order of release. Oral controlled DDS, factors affecting controlled release.
Carriers in DDS: polymers and their classification, types, carbohydrates, surfactants, proteins, lipids, prodrugs etc.
Transdermal drug delivery systems (TDDS): principles, absorption enhancers, evaluation of TDDS.
Parenterals: requirements, advantages, disadvantages, release pattern, route of drug delivery.
Drug targeting: microspheres, nano particles, liposomes, monoclonal antibodies, etc.
Preformulation detailed.
Complexation, solubilization, polymerization, viscosity measurements.
Dosage form development- stages, implications of dosage form.
Additives of formulation, types, examples, advantages, disadvantages, drug excipient interaction, incompatibility, various types of incompatibilities.
Dosage forms: solid (tablets, capsules, pills etc), liquid (emulsion, suspension etc), sterile (injectables), aerosols. Principles, advantages, disadvantages and problems.
Coating - in detail.
Packaging: materials, labeling etc. Types of containers (e.g. Tamper-proof containers)
In process controls, Product specification, documentation.
Compartmental modeling. (From Bramhankar)
Bioavailability, bioequivalence studies. Methods of improvement of oral bioavailability.
Evaluation of formulation, principles and methods of release control in oral formulations.
References:
1. Lachmann (ALL new and old techniques in Pharmaceutical Industry)
2. Alfred Martin (ALL physical chemistry BASICS)
3. Remington’s Pharmaceutical Sciences
4. Notes of Gudsurkar Sir (Most important)
5. Banker series.
6. other: Bramhankar, , Liberman Series

Pharmaceutical analysis:
Stability testing of pharmaceuticals, various stability tests, kinetic studies, shelf life determination, thermal stability, formulation stability.
Various analytical techniques
Tests: physical and chemical tests, limit tests, microbiological tests, biological tests, disintegration and dissolution tests.
Spectroscopic methods; UV, NMR, IR, MS, FT-IR, FT-NMR, ATR (Attenuated Total Reflectance), FT-Raman- basics and applications.
Thermal techniques: DSC, DTA, TGA, etc.
Particle sizing: law of diffraction.
Electrophoresis: capillary electrophoresis.
Chromatography- detailed.
QA and QC: GLP, TQM, ISO system.
Preformulation, cyclodextrin inclusion compounds
Solubility: pH, pka, surfactant HLB values, Rheology.
Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity, surface area flow properties.
Dosage forms, Stages of dosage form development
Osmolality, osmolarity, osmotic pressure, conductivity, Preservatives, Media for bioassay.
References:
1. Willard
2. Silverstein (Mass Spectroscopy)
3. William Kemp (NMR)
4. Pavia (for spectroscopy)
5. Others like Alfred Martin, Chatwal (UV), Garry Christen (Chemical Methods)

Biotechnology:Pharmaceutical technology biotechnology
Genetic Engg: Gene expression, mutation, replication, transcription, translation, recombination, bacteriophages.
Cloning: methods, isolation of nucleic acids, enzymes in cloning (restriction endonucleases, DNA ligase, DNA gyrase, polymerases etc...), functions of these enzymes, Pallindromes.
Fermentation: fermenters, fermentation process, its regulation, conditions, bioprocessors, various enzymes in fermentation technology. Fermentation of Antibiotics, vitamins, amino acids, hydroxy acids such as lactic acid etc. Chemical engg. aspects realated to fermentation
Gene therapy: methods and applications.
Monoclonal antibodies, insulin, interferons, enkephalins, angiotensin analogues and other peptides.
References:
1. Vyas and Dixit
2. IP Appendices

Practice of Pharmacy:
The best part for the preparation for this best reference for this would be Remington’s Pharmaceutical Sciences. This branch is quite new here, so till dates students of branch used to do case study of prescriptions in Fortis hospital, PGI Chandigarh and govt. college chd... This is much like pharmacology and drug-drug interactions and different interactions are emphasized. Diabetes, heart diseases are main area of study……….

Pharmacoinformatics:
Terminologies related with new emerging informatics e.g. proteomics, genomics, QSAR (2D, 3D, regression, correlation).
References:
Foye, Williams and Lemke, Medicinal chemistry, 5th/6th edition, chapter 1-6. (Computational drug design and molecular modeling).

Others:
Statistics, general mathematics and aptitude questions. Use MBA entrance test books like CET or CAT in MBA. Additionally some general awareness questions.
NIPER’s thrust areas are:
Microbial and viral diseases: Yeast, and fungi.
Parasitic and tropical diseases: Malaria, Leishmaniasis, amoebiasis, etc.
Metabolic Disorders: Diabetes
Strokes
Peptide and carbohydrate chemistry.
Genomics and proteomics: yeast and fungi
Hormonal disorders: TRH related diseases.
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Posted by PHARMA WORLD at 5/28/2010 01:44:00 PM
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Hello.
This a link where you will get pdf file of syllabus for Ph.D entrance exam.

http://www.pdffact.com/syllabus-of-ph-d-entrance-test-pet-2010.pdf

HELLO,
The P.hd entrance exam for NIPER conists of two sections consisting of Multiple Choice Questions. First section generally have 85 questions and compulsory for all candidates.Second section will have 3 parts with 85 questions and the candidates have to attempt one depending on the discipline in which they want to do their PhD.

The questions are from the syllabus of M. Pharma/ MS(Pharma)/MTech(Pharma)/MSc.(Relevant Field).

www.niper.gov.in

i completed m.pharmacy(pharmaceutics)in karnataka.i want to do phd in pharmaceutical sciences,please send the information about what are the entrance exams are available for phd.

hii

Syllabus of Ph.D entrance exam by NIPER
The P.hd entrance exam for NIPER conists of two sections consisting of Multiple Choice Questions. First section generally have 85 questions and compulsory for all candidates.Second section will have 3 parts with 85 questions and the candidates have to attempt one depending on the discipline in which they want to do their PhD.
The questions are from the syllabus of M. Pharma/ MS(Pharma)/MTech(Pharma)/MSc.(Relevant Field).

www.niper.gov.in

a link where you will get pdf file of syllabus for Ph.D entrance exam.

http://www.pdffact.com/syllabus-of-ph-d-entrance-test-pet-2010.pdf


for more info.. look into the attachment.

hai
i did m.pahrmacy (pharmaceutics) in kakatiya university. i want to get the notes of Gudsurkar sir. kindly help me.

Hello sir/madam,........
i had done M.Sc.Pharmaceutical Chemistry from Banasthali Vidyapith,Rajasthan, but i am not having net or gate qualified certificate,is there any other process to get admission in your institute without qualifying net/gate exam.
kindly reply me soon on [email protected] to prepare accordingly.

sir/madam
I have completed my MSc. in organic chemistry and I want to do my phd. in medicinal chemistry. please tell me the pattern of exam and what is the syllabus for that ?.
May you post your comment in my gmail account [email protected]
Thanking You

please give detailes of exact syllabus for phd exam

sir/madam please send exact syllabus for phd exam in niper and net csir

send me syllabus for niper phd

WHAT ARE DIFFERENT PHD ENTANCE EXAMS ARE THERE IN india?

what is the syllabus for msc chemistry in saastra university thanjavur

Originally Posted by nikhilmi

hello,
the p.hd entrance exam for niper conists of two sections consisting of multiple choice questions. First section generally have 85 questions and compulsory for all candidates.second section will have 3 parts with 85 questions and the candidates have to attempt one depending on the discipline in which they want to do their phd.

The questions are from the syllabus of m. Pharma/ ms(pharma)/mtech(pharma)/msc.(relevant field).

www.niper.gov.in

hi madam,
can you send me the detailed syllabus for phd entrance in pharmaceutics specialisation.

Originally Posted by nikhilmi

HELLO,
The P.hd entrance exam for NIPER conists of two sections consisting of Multiple Choice Questions. First section generally have 85 questions and compulsory for all candidates.Second section will have 3 parts with 85 questions and the candidates have to attempt one depending on the discipline in which they want to do their PhD.

The questions are from the syllabus of M. Pharma/ MS(Pharma)/MTech(Pharma)/MSc.(Relevant Field).

www.niper.gov.in

HI MADAM,
CAN YOU SEND ME THE DETAILED SYLLABUS FOR PHD ENTRANCE IN PHARMACEUTICS SPECIALISATION. MY MAIL ID IS [email protected]

please give modelpaper,syllbus for phd entrance in pharmaceutics specialisation my mail id [email protected] thanku

i am m.pharm(pharmaceutical quality assurance). am i eligible for Ph.D entrance exam by NIPER?

Hai sir/ madam...
I have done m.pharmacy( pharmacy practice). i want to do a phd in pharmacology. shell i know about the phd entrance perticular syllabus. and i want to know which spacialization is best for phd.and when is the phd entrance date for 2013 batch? . its my kindly request to give me a reply soon...thank you...