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Department of Human Genetics
Courses Run
B.Sc. (Honours School) three-year (Six Semesters) course
M.Sc. (Honours School) two-year (Four Semesters) course
M.Sc. (Honours) two-year (Four Semesters) course
Ph.D (Three – Five year course), One Semester course work is compulsory.
Courses offered/Distribution of seats

Course
Name
Duration
(Year)
System

Total Seats
Reserved Categories

SC/ST

BC

RA

Others

B.Sc. (Hons. School)

3
Semester
40
10
2
3
5
M.Sc. (Hons.)

2
Semester
30
7
2
2
4
Ph.D*

3 – 5
Semester
50
14
3
3
5
*Number of seats being offered each year for Ph.D may vary according to the vacancies available with the faculty.

Eligibility for admission and Mode of selection of students

· B.Sc. (Hons. School): Senior Secondary (10+2) examination in any science subject (any combination) with at least 50% marks in the aggregate, or any other examination recognized as equivalent thereto by Guru Nanak Dev University, Amritsar.
Admission will be based on merit of the candidate in the qualifying examination.
· M.Sc. (Hons. School): B.Sc. (Hons. School) degree in Human Genetics from Guru Nanak Dev University with at least 50% marks in aggregate or any other degree recognized as equivalent thereto by Guru Nanak Dev University.
Admission will be based on merit of the candidates in B.Sc. (Hons. School) Human Genetics.
· M.Sc. (Honours): B.Sc. degree (10+2+3 system of education) in any science subject (any combination) with at least 50% marks in aggregate from Guru Nanak Dev University, M.B.B.S., B.D.S., or any other examination recognized equivalent thereto by the University.
Admission will be based on merit of the candidates in Entrance Test conducted by the Department.
· Ph.D : Candidates with a Master Degree in Human Genetics or allied subject with 55% marks (50% for SC/ST).
Admission to Ph.D degree course will be made through an eligibility test to be conducted by the University. The qualifying candidates will also be eligible for fellowships offered by the University. Exemptions i) UGC/CSIR-J.R.F., N.E.T. or Equivalent qualified candidates. (ii) Approved teachers of University and colleges before the implementation of N.E.T.
Fee Structure of each course

Approx. Rs. 23,000-00 for B.Sc. (Honours School) Part-I (Semester-I/II)
Approx. Rs. 25,000-00 for M.Sc. (Honours) Part-I (Semester-I/II)
Major Equipment in the Department

Automatic DNA Sequencer (ABI PRISM 377), Automatic pipetter, Analytical Balances, Automatic Ice Flaker, Automatic Photomicrographic System, Bionocular Microscopes, Body Fat Analyser, Cold Centrifuge, CO2 incubators, Cold Room, ELISA Reader, Fluoroscent Microscope, Freezers, Hydridization Incubator, Inverted Microscope, Semi-Automatic Blood Analyser, Stereo Microscope, Thermal Cyclers, Vertical and Horizontal, Laminar Flow, Vertical PAGE apparatus, Water Purification Systems, Nucleic acid synthesizer, Manual sequencers, Hybridization Incubator, 2-D gel Electrophoresis system, Liquid Scintillation Counter, Gel Documentation System, Lyophiliser, Gene Pulsar, Pulse-field Gel Electrophoretic System.

Research Activities and Special Contributions of the Department

The department of Human Genetics was established in 1988 as part of School of Life Sciences under specific recommendations of the UGC. The discipline of Human Biology and Human Genetics came into existence as a separate department in 1990. It was renamed as the Department of Human Genetics in 1993. The Centre for Genetic Disorders was set up in the department in 1990 under a grant of Rs 1.57 Crores sanctioned to Prof. Dr Jai Rup Singh by the Department of Biotechnology, Govt. of India. As per the undertaking given to Govt. of India, the Guru Nanak Dev University took over the Centre after 5 years. The center for Genetic Disorders was merged with the Department of Human Genetics w.e.f April 1, 2010. Since its inception, the centre has been providing diagnostic services to cases suspected of chromosomal anomalies and guidance regarding future options to patients and families with genetic diseases. The clinical diagnostic and genetic counseling facilities at Centre for Genetic Disorders include ultrasound, ERG-VEP equipment, complete minor O.T. facilities, London Dysmorphology Data Base and Photo Library, London Neurogenetic Data Base, Mendelian Inheritance in Man, METAGENE (Data Base of Inborn Errors of Metabolism).

The research activities of the department pertain to molecular genetics, cytogenetics, growth and population studies. A multi-tier approach is underway for the comprehensive screening and evaluation of the spectrum of genetic diseases prevalent in the population groups of the northwest region of India. Genetic epidemiological surveys precede growth, cytogenetic and molecular investigations. Some databases for different genetic diseases have been set up and are being extended in view of genetic variations among the people inhabiting this region. The population and growth studies conducted on different populations of Punjab have provided important information about nutritional and anthropometric profiles of various caste groups. The database for various body morphological characteristics and body composition parameters of these populations has also been set up. The molecular genetic profile of various diseases, viz. cardiovascular diseases, hypertension, obesity, diabetes, eye disorders, cancer etc., is being investigated to evaluate the genetic susceptibility or resistance, if any, of certain individuals towards these diseases. A microsatellite laboratory for gene mapping studies established by Centre for Genetic Disorders is involved in mapping of genes in large families suffering from various genetic diseases. Research related to identification of genes causing various types of eye disorders is being undertaken. By positional cloning, mapping of the genes for some novel phenotypes of congenital cataract on chromosomes; 1, 3, 13, 14, 15, 16, 19, 21, and 22 has been successful. A novel locus and a novel gene for night blindness in an autosomal recessive night blindness family have been identified. Novel mutations in EXT1 & EXT2 genes linked and segregating with the disease phenotypes have been identified in autosomal dominant hereditary multiple exostoses (HME) families of Indian origin by linkage and mutation analyses.

A rich collection of data and samples from patients suffering from different genetic disorders and also from various population groups is being maintained at department. The repository of Center for Genetic Disorders has blood/DNA/lens samples from cases suffering from various eye disorders including congenital cataract, retinitis pigmentosa, Marfan's syndrome, familial myopia, Diabetic Retinopathy, Glaucoma and other ocular anomalies.

The research work of the faculty has been included in International databases i.e. Online Mendelian Inheritance in Man (OMIM), National Centre for Bioinformatics (NCBI) database and World Health Organization (WHO) database viz.

1. The research work of Dr.Jai Rup Singh and Dr. Vanita Kumar in OMIM
§ "central pouch-like" cataract with Y-sutural opacities mapped to 15q21-q22, OMIM No. : 605728.
§ sutural cataract with punctate and cerulean opacities mapped at 22q11.2-q12.1, OMIM No. : 607133.
§ cerulean cataract mapped to a novel locus at 16q23.1, OMIM No. : 610202. This cataract phenotype has been classified as cerulean cataract type-4.
§ posterior polar cataract mapped to a new locus at 14q, OMIM No. : 610634 and this phenotype is classified as posterior polar cataract type-5
2. The research work of Dr. Sharda Sidhu on “Prevalence of Anaemia in Preschool Children of Punjab” has been included in WHO database on Iron Deficiency/Anaemia.
3. Several novel SNPs and sequences of genes of Type-2 diabetes in NCBI gene bank as a part of the work of Dr. A.J.S Bhanwer
4. Gene sequences of two candidate genes for Psoriasis have been deposited in NCBI database as part of work of Dr. Gursatej Gandhi.

The Department of Human Genetics in collaboration with Centre of genetic disorders has organized five international symposia, many internationally collaborative hands-on-training workshops and lectures by renowned scientists of national and international repute. The department has undertaken 32 research projects since its inception in 1990 and a total research grant of Rs. 5.6 crores has been received. The research output of the department is reflected in the published work which includes four books and 241 research articles in Indian and foreign journals. The Centre for Genetic Disorders as part of the department is one of the leading centers of India providing diagnostic and genetic counseling services to the people of North West India. The department is a DST-FIST-sponsored department, and a UGC-SAP recognized department.

Best Five Publications (Faculty wise)



1



Dr. AJS Bhanwer

Kaur, I., Chakrabarti, S., Sarhadi, V.K., Roy, S., Majumder, P.P., Bhanwer, A.J.S. and Singh, J.R. (2002). Genomic diversities and affinities among four endogamous groups of Punjab (India) based on autosomal and mitochondrial DNA polymorphisms. Hum. Biol. 74: 819-836.
Rai, K., Sharma, S., Koul, A., Bhat, A.K., Bhanwer, A.J.S and Bamezai, R.N.K. (2007). Interaction between the UCP2-866G/A. mtDNA 10398G/A and PGCαр. Thr394Thr and р.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population. Hum. Genet. 122: 535-540. DOI 10.1007/s00439-007-421-424 (online).
Sharma, S., Rai, E., Bhat, A.K., Bhanwer, A.J.S. and Bamezai, R.N.K. (2007). A novel subgroup Q5 of human Y- chromosome haplogroup Q in India. BMC Evol. Biol. 7: 232.
Badaruddoza, Bhanwer, A.J.S., Sawhney, R., Randhawa, N.K., Matharoo, K. and Barna, B. (2009). A Study of Angiotension Converting Engyme (ACE) gene polymorphism in Essential Hypertension among a Business Community in Punjab. Int. J. Hum. Genet. 9 (3-4): 231-234.
Sharma, S., Rai, E., Sharma, P., Jena, M., Singh, S., Darvish, K., Bhat, A.K., Bhanwer, A.J.S., Tiwari, P.K. and Bamezai, R.N.K. (2009). The Indian origin of paternal haplogroup R1a1 substantiates the autochthonous origin of Brahmins and the caste system. J. Hum. Genet. Doi:10.1038/jhg.2008.2


2



Dr. Sharda Sidhu

Sidhu, S., Kaur, A. and Prabhjot (2005). Prevalence of overweight and obesity among urban and rural adult females of Punjab. Anthropolgischer Anzeiger 63: 341-345.
Sidhu, S., Marwah, G. and Prabhjot (2005). Prevalence of overweight and obesity among the affluent adolescent school children of Amritsar, Punjab. Collegium Antropologicum 29: 53-55.
Sidhu, S., Kaur, H. and Kaur, R. (2006). Overweight and obesity in affluent school children of Punjab. Annals of Human Biology 33: 255-259.
Sidhu, S. Luthra S and Kumari K (2007). Prevalence of hypertension in adult population of Punjab. Indian Journal of Physical Anthropology and Human Genetics. 26: 63-68.
Kapoor, M., Kapur, S., Mehra, S., Dube, U., Shard, S. and Sidhu, S. (2009). Genetic variation in D7S1875 repeat polymorphism of leptin gene is associated with increased risk for depression: a case control study from India. Depression and Anxiety. 26 (9) 791-795.


3

Dr. Gursatej Gandhi

Gandhi, G. and Singh, B. (2004). DNA damage in untreated and treated leprosy patients. Mutagenesis 19: 483-488.
Gandhi, G. and Anita (2005). Genetic damage in Mobile Phone users: Some preliminary findings. Ind. J. Hum. Gen. 11: 99-104.
Gandhi, G. (2007). A Sikh perspective on human genetic advances. Eub. J. Asian Int. Bioeth. 17: 115-119.
Gandhi, G. and Chopra G. (2009) DNA Damage in Peripheral Blood Leukocytes of Physically Active Individuals as measured by the Alkaline Single Cell Gel Electrophoresis Assay. Environmental & Molecular Mutagenesis, 50:291-303. Online DOI 10.1002/em.20457.
Gandhi, G. and Jeevan Jyoti (2010). Assessment of DNA damage in Peripheral Blood Leukocytes of Patients with Essential Hypertension by the Alkaline Comet Assay. Cytologia (in Press)
4

Dr. Vasudha Sambyal

Gupta, T., Batra, A.P.S., Sidhu, S and Sambyal, V. (2008) Association between Body mass index and esophageal cancer patients. Journal of Biotechnology 136 : S112
Kaur, H., Singh, A.P., Singh, G., Sidhu, S., Sambyal, V. (2009). Plasma Monocyte Chemoattractant Protein-1 as risk marker in Type 2 diabetes and Coronary Artery Disease in North Indians. Diabetes and Vascular Disease Research; 6 (4): 288-290.
Kaur, H., Kaur, G.M., Setia, N., Sudan, M., Uppal, M.S., Yamini., Batra, A.P.S., Sambyal, V. (2009). Chromosomal instability in the lymphocytes of breast cancer patients. Indian Journal of Human Genetics. 15 (1) 13-18.
Guleria, K. and Sambyal, V. (2010). Spectrum of Chromosomal Aberrations in Peripheral Blood Lymphocytes of Gastrointestinal Tract (GIT) and Breast Cancer Patients. International Journal of Human Genetics 10 (1-3): 147-158.
5

Dr. Vanita Kumar

Vanita, V., Sperling, K., Sandhu, H.S., Sandhu, P.S., Singh, J.R. (2009). Novel EXT1 and EXT2 Mutations in Hereditary Multiple Exostoses Families of Indian Origin. Genetic Testing and Molecular Biomarkers, 13: 43-49.
Vanita V, Daljit Singh, Peter N Robinson, Karl Sperling, Jai Rup Singh (2006) A novel mutation in the DNA binding domain of MAF at 16q23.1 associated with autosomal dominant “Cerulean Cataract” in an Indian family. Am. J. Med. Genet. 140: 558-566.
Vanita, V., Hennies, H.C., Singh, D., Nuernberg, P., Sperling, K., Singh, J.R. (2006). Novel mutation in GJA8 associated with autosomal dominant congenital cataract in a family of Indian origin. Molecular Vision 12: 1217-1222.
Vanita, Singh, J.R., Sarhadi, V.K., Singh, D., Reis, A., Ruschendorf, F., Follmann, J.B., Jung, M. and Sperling, K. (2001). A novel form of ‘central pouch-like cataract with sutural opacities’ maps to chromosome 15q21-22. Am. J. Hum. Genet. 68: 509-514.
Vanita, Sarhadi, V.K., Reis, A., Jung, M., Singh, D., Sperling, K., Singh, J.R. and Buerger, J. (2001). A novel form of autosomal dominant cataract explained by gene conversion between the B-crystallin gene CRYBB2 and its pseudo-gene CRYBP1. J. Med. Genet. 38: 392-396.
6

Dr. Anupam Kaur

Kaur, A. and Singh, J.R. (2010). Chromosomal abnormalities: genetic disease burden in India. Int. J. Hum. Genet. 10(1-3): 1-14.
Kaur A, Mahajan, S., Singh, J.R. (2009). Aging and Genetic Disorders: An experience with Down syndrome. Wiener Klinishe Wochenschrift-The Middle European Journal of Medicine (online): 121: 10-11.
Kaur, A., Dhillon, S., Garg, P.D., Singh, J.R. (2008). Ring chromosome 7: In an Indian Woman. J. Intellect. Dev. Disabil. 33(1): 87-94
Bashamboo A, Bhatnagar S, Kaur A, Sarhadi VK, Singh JR and Ali S. (2003) Molecular characterization of Y-derived marker chromosome and identification of indels in the DYS1 region in a patient with stigmata of Turner Syndrome. Current Sci. 84 (2) : 219-249.
Grover I.S, Kaur A, Mahajan RK, (1995). Mutagenicity of some dye effluents, Ind. Natl. Acad. Sci. 19 (7&8) : 149-158.




7



Dr. Badaruddoza

Badaruddoza and Afzal M (1993). Inbreeding depression and intelligence quotient among North Indian children. Behaviour Genetics 23: 343-347.
Badaruddoza, Afzal M and Akhtaruzzaman (1994). Inbreeding and Congenital Heart Diseases in a North Indian Population. Clinical Genetics 45: 288-291.
Badaruddoza (2004). Inbreeding effects on metrical phenotypes among North Indian Children. Collegicum Antropologicum 28(Suppl. 2): 311-318.
Badaruddoza (2004). Effect of inbreeding on Wechsler intelligence test scores among North Indian Children. Asia Pacific Journal of Public Health 16(2): 99-103
Badaruddoza and Punarjot Kaur (2010). Familial patterns of blood pressure with respect to anthropometric variables among Lobana (Nomadic origin) population in Punjab, India. Asia Pacific Journal of Public Health. DOI: 10.1177/1010539508372539.


8



Dr. Manpreet Kaur

Kaur, M., Singh, K., Rup, P.J., Kamboj, S.S., Singh, J. (2009) Anti-insect potential of lectins from Arisaema species towards Bactrocera cucurbitae. Journal of Environmental Biology 30(6), 1019-1023.
Kaur, M., Singh, K., Rup, PJ., Kamboj, SS., Saxena, AK., Sharma, M., Bhagat, M., Sood, SK., Singh, J. (2006). A tuber lectin from Arisaema jacquemontii Blume with anti-insect and anti-proliferative properties. J. of Biochem and Mol Biol. 39: 432-440.
Kaur, M., Singh, K., Rup, PJ., Saxena, AK., Khan, R., Tashfeen, A., Singh, S. and Singh, J. (2006). A tuber lectin from Arisaema helleborifolium Schott with anti-insect activity against Bactrocera cucurbitae (Coquillett) ant anti-cancer effect on human cancer cell lines. Arch Biochem Biophys. 442: 156-165.
Kaur, N., Singh, J., Kambnoj, SS., Agrewala, JM., Kaur, M. (2005). Two novel lectins from Parkia biglandulosa and Parkia roxburghii: Isolation, physicochemical characterization, Mitogenicity and anti-proliferative activity. Protein and Peptide Lett. 12: 589-595.
Kaur, M., Singh, J., Singh, S., Singh, J., Kaur, A., Sood, SK. and Saxena AK (2005). Isolation and Characterization of N-acetyl-D-lactosamine specific lectin from Arisaema intermedium Blume and Arisaema wallichianum Hook. F. Indian J Biochem Biophy. 42: 34-40.


9



Dr. Kamlesh Guleria

Roy, F.H., Singh, D., Guleria, K., Singh, R.S. (2005) Comprehensive Classification of Pediatric Cataracts. Ann Ophthalmol, 37(3):157-183.
Guleria, K., Sperling, K., Singh, D., Varon, R., Singh, J.R., Vanita, V. (2007). A novel mutation in the connexin 46 (GJA3) gene associated with autosomal dominant congenital cataract in an Indian family. Mol. Vis. 13: 1657-1665.
Guleria, K., Vanita, V., Singh, D., Singh, J.R. (2007). Novel “pearl box cataract” associated with mutation in the connexin 46 (GJA3) gene. Mol. Vis. 13: 797-803.
Guleria, K. and Sambyal, V. (2010). Spectrum of Chromosomal Aberrations in Peripheral Blood Lymphocytes of Gastrointestinal Tract (GIT) and Breast Cancer Patients. Int. J. Hum. Genet. 10(1-3): 147-158.
Saxena, R., Kohli, S., Guleria, K., Verma, I.C. (2010).p53: Li Fraumeni Syndrome (LFS), 48 compiled in Novel human pathological mutations. Human Genetics, 127: 463-490.




Ongoing Research Projects in the Department

Title of the Project

PI/Co-I
FundingAgency
Amount (Rs.)
Period
Centre of Excellence in Sports Sciences
Dr. A.J.S. Bhanwer
Dr. Gursatej Gandhi
UGC
New Delhi
30.00 Lakhs
2007-2010
Analysis of Genetic determinants of T2DM and their role in its susceptibility in some North-West Indian population groups.
Dr. A.J.S. Bhanwer
Dr. Vasudha Sambyal

DBT
New Delhi
16.75 Lakhs
2008-2011
Molecular genetic analyses in diabetic retinopathy cases
Dr. Vanita Kumar

DST, SERC Fast Track Scheme
18.96 Lakhs
2008-2011
Assessment of VEGF Polymorphisms and Serum Vascular Endothelial Growth Factor (sVEGF-C) level as Prognostic Marker for Breast Cancer
Dr. Kamlesh Guleria,
Dr. Vasudha Sambyal

DBT
16.08 Lakhs
2009-2012
Study of Adiponectin Levels and Single Nucleotide Polymorphisms in the Adiponectin Gene in Type 2 Diabetic Women
Dr. Kawaljit Kaur
Mentor:
Dr. A.J.S. Bhanwer
DST
(DST-WOS-A)
17.88 Lakhs
2009-2012
Molecular Studies of Alcoholism in SC Population of Punjab
Dr. A.J.S. Bhanwer
UGC
11.72 Lakhs
2010-2013
Metabolic Genotypes as Modulators of DNA and Chromosomal Damage in Persons Engaged in Quarrying/Stone Crushing
Dr Gursatej Gandhi
DST
18.80 Lakhs
2010-2013
Genetic polymorphism of MTHFR: Its implication as maternal risk factor for Down Syndrome
Dr. Anupam Kaur
UGC
8.61 Lakhs
2010-2013
























Faculty : Professor 2, Reader 4, Lecturer 3



Dr. A J S Bhanwer

Qualification
Ph.D.

Designation
Professor
Area of Specialization
Human Molecular Genetics
Area of Interest
Molecular genetics of Complex Diseases
No. of Publications
24
Email Address
[email protected]
[email protected]

Contact Numbers
(O) 0183-2450601,ext 3278,
(M) 09814103474
Dr. Sharda Sidhu

Qualification Ph.D. (Human Biology)


Designation Professor
Area of Specialization Human Growth and Population Studies
Area of Interest Epidemiology
No. of Publications 80
Email Address [email protected]
[email protected]
Contact Numbers
(O) 0183-2258802-09 (O) Extn 3280 (R)91-183-2257639

(M) 9988070447

Dr. Gursatej Gandhi

Qualification Ph.D.


Designation Reader
Area of Specialization Human Genetics and Cytogenetics; Genetic Toxicology
Area of Interest Human Genetics and Cytogenetics; Population Biomonitoring; Bioethics
No. of Publications 68
Email Address [email protected]
[email protected]
Contact Numbers (O) 0183-2258802-09 Extn 3444 ( R ) 0183-2506600
Dr. Vasudha Sambyal

Qualification M.Sc., Ph.D.


Designation Reader
Area of Specialization Human Cytogenetics
Area of Interest Cancer Cytogenetics
No. of Publications 19
Email Address [email protected]
[email protected]
Contact Numbers (O) 0183-2258802-09 Extn. 3445, (R) 0183-2255331, (Mobile) 9569555331
Dr. Vanita Kumar

Qualification
M.Sc., Ph.D., Post-doctorate trainings at Freie & Humboldt University, Berlin, Germany, National Eye Institute (NEI), National Institute of Health (NIH), Bethesda, Maryland, USA

Designation Reader & Head
Area of Specialization
Human Molecular Genetics and Biochemical Genetics
Area of Interest
Genomics & Proteomics
No. of Publications
21
Email Address
[email protected]
Contact Numbers
0183-2258802-09; Ext. 3277,3279
(M) 98726-94099
Dr. Anupam Kaur

Qualification
Ph.D.
Designation Reader
Area of Specialization
Cytogenetics/Molecular cytogenetics
Area of Interest
Genetic diagnosis and counseling
No. of Publications
16

Email Address
[email protected]
Contact Numbers
(O) 0183-2248802-09, Extn. 3446;3447
(M) 9872239393
Dr. Badruddoza

Qualification M.Phil., Ph.D.


Designation Sr. Lecturer.
Area of Specialization Human Population genetics
Area of Interest Human Evoluation
No. of Publications 55
Email Address [email protected]
[email protected]
Contact Numbers
(O) 0183-2258802-09 Extn. 3497
(R) 01832255203
(Mobile) 9815631536

Dr. Manpreet Kaur

Qualification M.Sc., Ph.D.


Designation Lecturer.
Area of Specialization Immunology And Animal Cell Culture
Area of Interest Immunogenetics
No. of Publications 9
Email Address [email protected]
Contact Numbers
(M) 9888475886

Dr. Kamlesh Guleria

Qualification M.Sc., Ph.D.


Designation Lecturer.
Area of Specialization Human Molecular genetics
Area of Interest Molecular Genetics
No. of Publications 9
Email Address [email protected]
Contact Numbers
(O)0183-2258802 - 09 Extn.3250

(M) 9815948779



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i have completed my 2 class in a medical stream,i want to do M.B.B.S. i want to know what is the main study in this degree,is of how many years?..is this degree available in G.N.D.U?????

is it necessary to give entrance test for b.tech in gndu

how many seats for punjab students in M-Tech in cse , and what is the procedure to get admitted in university.

How many seats available at the time for b.com in gndu